Rectal Ozone

Rectal insufflation with an O3/O2 gas mixture is increasingly being used as a systemic therapeutic form, and is viewed by many as an alternative to MAH. It is the method of choice in pediatrics.


  • lcerous colitis
  • Proctitis, stages I and II
  • Anal fistulae and fissures

  • Indications cited for MAH
  • Hepatitis B and C
  • For immunomodulation

Rectal ozone application is simple, low-cost and practically free of adverse reactions when dosages are adhered to.


Go to

page 14 table 5 for dosing suggestions.

It is often recommended that an enema or colonic of some kind be used prior to the insufflation.

Cuban literature recommends an ozone concentration of 40 μg/ml and 200 ml, for a duration of 20 daily sessions
German literature recommends rectal insufflation 10–25 μg/ml max. 300 ml


Russian literature says the procedures are done with Janet syringe or with a help of special poly-chlor-vinil tube with a patient lying on the left side with knees bent. Purgative enema is to be done two hours before the procedure. Rectal insufflations are done with the ozone concentration in ozone/oxygen mixture of 10-60 mg/l, the volume ranges from 150 ml to 1,000 ml, depending on the pathology, its course and stage. For newborns the volume is 20-50 ml, for children it is 50-100 ml (H. Dorstewitz, 1990).


American authors set the following concentration levels:

  • 1st treatment – 20 μg/ml  and 100 cc
  • Increase daily by increments of 5 gamma and reach a final gamma of up to 40 μg/ml and up to 400 cc or as the patient can tolerate.  This continues for a 21-day cycle, stops for 2 months and then repeats if needed.


Conservatively the Madrid Declaration puts rectal ozone in three application doses.

Low           10 μg/ml and 100 ml
Medium     20 μg/ml and 100 ml
High          30 μg/ml and 150 ml LOW RANGE

  • Biological regeneration
  • Gout
  • Fibromyalgia LOW-MIDDLE RANGE

  • Chronic kidney failure
  • Cancer
  • Nephropathies MIDDLE RANGE

  • Neurovegetatives illnesses: Alzheimer, parkinson, dementia syndromes.
  • Pulmonary illnesses: Emphysema, COPD, acute respiratory distress syndrome.
  • Ophthalmological illnesses: Retinosis pigmentarias, cataract, glaucoma, macular degeneration related to age.
  • Hematology illnesses: Thalassaemia B, scklemia.
  • Vascular Illnesses: HTN, venous insufficiency, peripheral arterial illness, CVA, cardiacs ischemia, veined stasis. MIDDLE-HIGH RANGE

  • Viral Illnesses: Herpes simple, herpes zoster, AIDS, hepatitis A, B, C, human papilloma virus.
  • Diabetes
  • Cerebral palsy
  • Dermatological illnesses
  • Orthopedic illnesses
  • Giardiasis
  • Candidiasis and cryptosporidiosis.
  • Allergic illnesses
  • Chronic fatigue syndrome
  • Lupus erythematosus systemic
  • Rheumatoid arthritis
  • Crohn’s illness
  • Intestine inflammatory illnesses
  • Multiple sclerosis


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