4 Stages of Wound Healing 2018-01-21T20:06:35+00:00

The Four Stages of Wound Healing

Use of ozone for wound healing is a two-phase process:

Phase 1 – Kill the bacteria and viruses in the wound – use ozone gas – 60 to 80 gamma, full ozonated water or strong ozonated oils – Three times per day for first two days

Phase 2 – Promote healing through increased oxygenation – ozone gas – 20 gamma or milder ozone oil – Three times per day for two weeks

See Bocci on Ozonated Oils study

There are also four stages of wound healing:

1) Hemostasis

  • Damaged blood vessels constrict, platelet plugs form and blood coagulates.
  • Platelets and damaged cells initiate reactions ultimately resulting in fibrin threads and clot formation.

2) Inflammation Phase

  • Swelling and warmth often associated with pain.
  • The inflammatory response causes the blood vessels to become leaky releasing plasma and neutrophils into the surrounding tissue.This cleans up debris and fights infection.
  • The area exhibits redness and swelling accompanied by heat and pain.
  • Macrophages are able to phagocytize bacteria and provide a second line of defense. They also direct the next phase of healing.

3) Proliferative Phase (Proliferation, Granulation and Contraction)

  • The granulation stage starts four days after wounding and can last up to three weeks in acute wounds.
  • Fibroblasts secrete the collagen framework upon which further dermal regeneration occurs.
  • Pericytes regenerate the outer layers of capillaries and the endothelial cells which produce the lining.
  • Specialized fibroblasts are responsible for wound contraction. Keratinocytes are responsible for epithelialization.

4) Remodeling or Maturation Phase

  • The healing process involves remodeling the dermal tissues to produce greater tensile strength by the fibroblasts.
  • Remodeling can take up to two years after wounding.