The Four Stages of Wound Healing
Use of ozone for wound healing is a two-phase process:
- Kill the bacteria and viruses in the wound
- Use ozone gas of 60 to 80 gamma, full ozonated water or strong ozonated oils
- Administer three times per day for the first two days
- Promote healing through increased oxygenation
- Use zone gas of 20 gamma or milder ozone oil
- Administer three times per day for two weeks
See Bocci on Ozonated Oils study.
Wounds heal in 4 stages:
- Damaged blood vessels constrict, platelet plugs form, and blood coagulates.
- Platelets and damaged cells initiate reactions, ultimately resulting in fibrin threads and clot formation.
2) Inflammation Phase
- Swelling and warmth often associated with pain.
- The inflammatory response causes the blood vessels to become leaky releasing plasma and neutrophils into the surrounding tissue. This cleans up debris and fights infection.
- The area exhibits redness and swelling accompanied by heat and pain.
- Macrophages are able to phagocytize bacteria and provide a second line of defense. They also direct the next phase of healing.
3) Proliferative Phase
- The granulation stage starts four days after wounding and can last up to three weeks in acute wounds.
- Fibroblasts secrete the collagen framework upon which further dermal regeneration occurs.
- Pericytes regenerate the outer layers of capillaries and the endothelial cells which produce the lining.
- Specialized fibroblasts are responsible for wound contraction. Keratinocytes are responsible for epithelialization.
4) Remodeling or Maturation Phase
- The healing process involves remodeling the dermal tissues to produce greater tensile strength by the fibroblasts.
- Remodeling can take up to two years after wounding.