Ozone Therapy for Eye Disease
Ozone has an unprecedented history of success in the treatment of several eye disorders.
The most common ophthalmologic diseases include:
- Primary Glaucoma
- Optic Nerve Dysfunction
- Macular Degeneration
- Retinitis Pigmentosa
Ten Year Study in Patients Suffering from (Tunnel Vision and Decreased Night Vision) and Treated with Repeated Cycles of Ozone Therapy.
Retinitis Pigmentosa is an hereditary disease of the retina which produces night blindness, peripheral visual field loss and narrowing of the central vision, which degenerates, after several years, in total blindness. This disease affects approximately 0.5% of the world population and it is estimated that in Cuba suffer this disease, 3.1 per 10,000 habitants, with a great incidence in the central and west region of the country. In Cuba, it has been using ozone therapy like part of the treatment of Retinitis Pigmentosa, since November 1986, in “Salvador Allende” University Hospital. A study of the clinical evolution of 20 patients that have been treated (between 5 and 10 years) with repetitive cycles of ozone therapy was performed. No other therapy was associated. The ways of ozone application was autohemotherapy or rectal insufflation.
A complete ophthalmologic examination was performed during this period. Snellen visual acuity, considering significant changes more than 2 lines and Goldmann kinetic visual field (V-4e target), considering significant changes increase in more than 10 grades and/or appearance of peripheric windows, were analyzed. The best results were achieved when ozone treatment is repeated, at least, twice a year, along all these years, with improvement of 70% in the visual field and 42% in the visual acuity. The rest of the patients maintained their visual field or visual acuity the same as the initial value, without worsen the disease. Any side effect was observed. The satisfactory results encourage to recommend its use in patients affected by Retinitis Pigmentosa.
M. Copello, S. Menéndez, I. Horrach, J. Betancourt; National Reference Center of Retinitis Pigmentosa; Salvador Allende University Hospital, Cuba; Ozone Research Center,Cuba.
Controlled Clinical Trial on the Use of Ozonated Blood as a Treatment for Retinitis Pigmentosa.
The aim of this study is to determine the effects of ozone as a therapy for patient with retinitis pigmentosa. A double blind, placebo controlled study was designed, in which 123 patients, ages 15 to 65 years, and suffering from typical forms of retinitis pigmentosa participated Sixty two patients were randomly assigned to the treatment group and 61 to the control group.
A complete general and ophthalmologic examination was performed after signing an informed consent Snellen visual acuity was measured (less than 2.5 lines considered non significant changes) and Goldmann kinetic visual field with 31.5 asb. background and V-4e target. Visual field areas were digitized and measured with a computer program (VISUAL). Ozonated blood was administered to patients in the treatment group, in a daily fashion for 15 days, while patients in the control group received only blood. Participants were blind with regards to this, throughout the duration of the study. Visual acuity remained the same, 6 months after the treatment, in 74.2% of the patients, improve in 21% and worsen in 4.8 %. Visual field area remained the same, 6 months after the treatment, in 41.9% of the patients, improve in 46.7% and worsen in 11.35%.
Significant differences were observed between groups, with lower frequencies of improvements in controls are larger proportions of worsening. Improvements were not observed in 91.9% of patients one year after the treatment. This tendency was first noted after 6 months from the treatment. Ozone treatment is proved of benefit in patients with RP, although its action is temporary .Repeated administration after 6 months is recommendable to maintain its action.
N. Moreno, O Pelaez, T. Aleman, C. Barcelo. International Reference Center of Retinitis Pigmentosa “Camilo Cienfuegos”, Cuba.
Effects of Ozone in Patients with Retinitis Pigmentosa.
The effects of ozone in 50 patients with retinitis pigmentosa was evaluated in the Retinitis Pigmentosa Center, Camagüey, Cuba. The patients suffer of photophobia abnormal intolerance to visual perception of light), photopsia (flashes of light) and reduce vision on dark places.
Considering that the patients with remission of two symptoms of the disease after the ozone treatment is considered as signs improvement, in this case all of them after the 7th and 8th ozone application didn’t present photophobia and phototopsia, increasing also the quality of their vision (by means of improvement in the visual acuity and visual field). In spite of, after 6 month the appearance of signs and symptoms in all the patients took place. It is considered that the results are important and very useful as alternative in patients that not admit the surgery, repeating it twice a year.
Y. Mapolon, M. Palma, E. Resio, M. Rodríguez, E. Dyce, C. Harrys, J. C. Pina. Retinitis Pigmentosa Center, Camagüey, Cuba. Dr. Eduardo Agramonte Pina Children Hospital, Camagüey, Cuba.
Ozone Therapy in Different Opthalmologic Diseases.
Since 1992, we have been using ozone therapy in our province, like a new therapeutic option in the treatment of Retinitis Pigmentosa. Taking into account the different medical properties of ozone: Improvement of the oxygen transportation to tissue, activation of the enzymes participating in peroxide or oxygen radical scavenging, immunological and metabolic modulator, as well as to be a therapy ease to apply, we decided to use ozone therapy in others ophthalmologic diseases.
180 patients were treated with daily rectal ozone therapy, during 20 days, representing
- 80 with Retinitis Pigmentosa (no systemic, stage I and II),
- 45 with progressive myopia,
- 25 with chronic glaucoma of open angle (tonometrically compensated),
- 20 with optic atrophy (less than one year of evolution and not hereditary),
- 10 with diabetic retinopathy (no proliferative).
Healing criteria was according to each disease. Clinical evaluation was made each 3 months, up to 1 year. In patients with:
Retinitis Pigmentosa, 75% improved their visual acuity (post-treatment and 6 months later). After 1 year, 23% of improvement still remained. According to visual field, 76% of patients improved it after treatment and up to 9 months, but after 1 year, 16% lost their improvement.
Progressive myopia, the visual acuity increased in 78% (post-treatment and 9 months later) and remained 58% after 1 year.
Glaucoma, 65% increased the visual acuity (post-treatment and 9 months later), maintaining 53% of improvement after 1 year. Visual field increased in 76% of patients, post-treatment and after 1 year.
Diabetic retinopathy, 60% improved their visual acuity (post-treatment), diminishing to 40%, 6 months later and 20%, after 1 year.
Optic atrophy, 45% of improvement in visual field was achieved (post-treatment) maintaining its figure after 1 year.
It is concluded that ozone therapy offers very good results in this opthalmologic diseases, without side effects, being necessary to repeat the treatment in dependence of the disease and the patient evolutions.
E. C. Díaz, L.Borrego, S. Menéndez, L. R. Borrego, R. A. Borrego. V.I.Lenin; Provincial Hospital, Holguín, Cuba. Provincial Center of Retinosis Pigmentaria, Holguín, Cuba.Ozone Research Center, Cuba. Faculty of Medicine, Holguín , Cuba.
Rehabilitation of Patients with Primary Glaucoma of Open Angle Under Sanatorial Regimen.
Primary glaucoma of open angle is a disease that can invalidate man in different stages of his physical labor and intellectual life. Several studies in various countries, placed it among the world three primary causes of visual blindness invalidity. Studies carried out by Health World Organization in 1992 reported it as the second cause of blindness in Latin America and the first in the Caribbean area. It is a kind of multifactorial disease for which does not exist a unique solution. Therefore, this element has to be taken into account at the time of a medical therapeutic. Ocular hemodynamic changes are an important factor which play a fundamental role in the raise and development of a glaucoma process. The nervous system participation is another aspect to be considered in this disease. During the first decades of this century a link between the ocular tone and vegetative nervous system has been established. Beside this, rehabilitation treatment with relaxation techniques under sanatorial regimen had been introduced and thereby various factors had contributed to improve its treatment.
131 patients (251 eyes) with diagnosis of open primary angle glaucoma with ages between 20 to 79 years old, remained during 21 days in Escambray Kurthotel “Topes de Collantes”, between January 1995 and October 1996. Visual function and ocular hydrodynamic had been studied in those patients, which were treated with ozone or ozone with magnetic field. Two subgroups had been created: one of then received local medical treatment with Timolol and the other without local treatment. Improvement in the visual functions as well as in ocular hydrodynamic were achieved. Mechanism of action is also reported.
L. Ferrer, I. Fernández, M. Ibañez, A. Rodríguez, F. Varela, D. Santos, B. Lazo, R. Marin, I. Jiménez, J.R. Amaro. Carlos J. Finlay Military Hospital, Cuba. Escambray Kurthotel Topes de Collantes, Cuba.Octavio de la Concepci—n y de la Pedraja Hospital, Cuba.
Ozone Therapy in Patients Suffering from Optic Nerve Dysfunction.
One of the most frequent causes of blindness around the world is optic nerve dysfunction (OND), or optic atrophy, which can be the result of different disturbances affecting the visual pathway like ischemic, toxic, metabolic and hereditary-degenerative phenomena, injuries or compression, among others, producing this type of irreversible sequel. The main object of this study is to evaluate the feasibility to improve the visual function of a group of patients, with different degrees of OND with reduced possibilities of vision improvement, by means of ozone therapy. To 60 patients, suffering from OND of different etiologies and time of evolution, were applied the mixture ozone/oxygen endovenously by autohemotherapy, during 15 sessions. Ozone concentration and doses are used according to the biochemical status of each patient. An ophthalmological examination and a set of tests conformed by visual acuity (VA), visual field by Goldmann Perimetry (VF), visual evoked potentials (VEP), Pelli Robson Contrast Sensitivity Test (PRCST) was applied to patients before and after ozone therapy treatment. PRCST and VF were the parameters mostly improved in patients with 86% and 83% respectively, followed by VA (55%) and VEP (37%). Good results were achieved in all etiologies studied, except Leber optic atrophy, where no improvement was observed, neither objective nor subjective.
R. Santiesteban, S. Menéndez, M. Francisco, S. Luis. Institute of Neurology and Neurosurgery, Cuba. Ozone Research Center, Cuba.
Application of Ozone in Patients with Keratitis.
Since February 1996, 120 patients with keratitis were treated in the Retinitis Pigmentosa Center of Camagüey, Cuba. 60 patients (sample) were treated with ozone and 60 patients (control group) with conventional treatment (yodoxuridine, leuferon, homatropine, vitamin therapy). 35 males and 45 females, between 15 and 35 years old presenting photophobia and feeling of strange bodies in their eyes were evaluated. At the present, this disease has a long course and the conventional treatment is very expensive, mostly because of the medications it requires. The ozone treatment was rectal application and subconjunctival way, combining both. After the first week, all the patients treated with ozone started to show signs of improvement and they were totally cured after 3 weeks, while in the control group, the evolution had a long course, more than 6 months. We concluded that ozone therapy brings very positive results in the treatment of this disease.
J.C. Pina, Y. Mapolon, M. Palma, E. Recio, C. Harrys, M. Rodríguez. Dr. Eduardo Agramonte Pina Children Hospital, Camagüey, Cuba. Retinitis Pigmentosa Center, Camagüey, Cuba.
Amblyopia by Anisometropia. A New Therapeutic Method.
Thirty adult patients with the diagnosis of amblyopia by anisometropia were studied. The majority of the patients had high ametropia, predominantly myopia. Ozone therapy was used, associated to the usual treatment of visual exercises and macular stimulation. The use of ozone associated to traditional methods produced a better and more effective response in the recovery of the patient visual acuity, as well as shortening the treatment.
A. Torrado, R. Wong, G. Soto. Medical and Surgical Research Center, Cuba.
Ozone Therapy in Patients with Diabetic Retinopathy.
The aim of this paper is to evaluate the efficacy of ozone therapy in the treatment of Non-Proliferative Diabetic Retinopathy (NPDR), an ocular complication of diabetes. Twenty five patients were examined through clinic biometry, in order to confirm the absence of other complications of diabetes. The inclusion criteria were: patients between 40 and 60 years old, males and females who suffered loss of visual acuity produced by retinal changes due to diabetic retinopathy. Patients were treated with ozone, by rectal insufflation, at concentration between 35-40 mg/L and 200 mL, one daily, for 15 sessions. This cycle of treatment was repeated every six months, up to 2 years. An ophthalmologic evaluation (visual acuity, direct and indirect ophthalmoscopy, retinophoto and fluorescein angiography) of the patients was performed at the beginning and at the end of every cycle of ozone therapy.
In 72% of the patients a visual improvement was achieved, with a slow disappearance of microaneurysm, intraretinal hemorrhages, hard exudates, microhemorrhages and retinal edema. From the second cycle on, this improvement was maintained in direct relation with a clinic biometry within the normal parameters (cholesterol, glycemia and creatinine), mainly on patients who suffered from Diabetes type II. No visual improvement was observed in the rest of the patients (28%) during 2 years of follow-up. An appropriate metabolic control of patients who suffer from mild NPDR was achieved, allowing a favorable recovering of their vision, as well as an improvement in their quality of life. On the basis of the stimulant effect of medical ozone in the processes of oxygen metabolization and blood circulation we can recommend this therapy for the treatment of patients suffering of Non-Proliferative Diabetic Retinopathy.
Hernández R., Ramírez T., Guerrero M., Betancourt J., Rubio L. and Izquierdo N. (Cuba)
Ozone Therapy in Senile Macular Degeneration.
Taking into account the incidence of senile macular degeneration (SMD) and low efficacy of conventional treatment, the aim of this study is to evaluate the efficacy of ozone therapy in patients with SMD of dry type. A retrospective study was performed in 22 patients assisted at the Ophthalmologic Service of the Medical Surgical Research Center (CIMEQ). Patients were diagnosed through a complete ophthalmologic examination and fluorescent angiography. Ozone was applied by major autohemotherapy (at an ozone concentration of 40 mg/L and 100 mL) and by rectal application (at an ozone concentration of 40 mg/L and 200 mL), during 20 sessions. A high percent of patients (54.5%) treated were between 61 and 70 years. White race predominate (45.4%), as well as female sex (68.2%). The results demonstrated an improvement (with an average of 2 tenths-visions) of their visual acuity in 80% of the patients treated with ozone. Ozone therapy could be a good therapeutic choice for patients suffering of SMD of dry type.
Soto G., Falcón J., Montesino I. and Soler L. (Cuba)