Ear Ozone Therapy is said to be useful for ear infections, sinus infections, mold toxicity, Lyme disease, and more

What is Ear Insufflation Ozone Therapy?

Using an oxygen tank and a small medical grade ozone generator (the size of a brick), a gas mixture of ozone and oxygen is created and pumped into the ears over the course of a few minutes. It is said to be useful for ear infections, sinus infections, mold toxicity, lyme, and more. Ozone ear insufflation is usually self-administered at home with supplies acquired online or administered at a doctors office. Most people do it at home for chronic, recurring, or severe issues.

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Ozone is a molecule comprised of three oxygen atoms, O3. Oxygen is comprised of two oxygen atoms, O2. Ozone is an unstable molecule and will quickly revert back to oxygen (O2). This instability is where the proposed benefits are derived from. Using a medical grade ozone generator, medical grade ozone-oxygen mixtures may harness therapeutic benefits, and in this instance, the alleged resolution of ear infections and other issues.

As always, it is recommended that you seek advice from a medical practitioner prior to using ozone.

Uses of Ozone Therapy

  • Ear Infections
  • Sinus Infections
  • Throat Infections
  • Fungus
  • Mold toxicity
  • Colds
  • Sore throat
  • Swollen glands
  • Anecdotal, backed by common report and not research
    • Lyme
    • Brain related issues
    • Pain in the neck or head

Benefits of Ozone Therapy

  • Inactivates and kills bacteria, protozoa, yeast fungi, and virus
  • May improve circulation
  • May decrease inflammation
  • May improve oxygen efficiency and usage
  • May increase energy
  • May stimulate growth factors in the ear
  • May decrease brain fog and stimulate positive effects in the brain

Effects of Ozone on the Ear Canal

In the ear canal, ozone primarily serves as a disinfectant by killing off pathogens. It has also been observed that ozone may stimulate growth factors on the skin, necessary for repairing of damage. It is postulated that ozone may stimulate the same result in the ear, even though the skin is a different tissue than found in the ears.

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Effects on the Sinuses

Practitioners often use ozone for sinus infections, blockages, and issues. It is believed that the effects of ozone are able to travel throughout the sinus cavity through the tubes connecting the ear and sinus.

Effects on the Brain

Beyond anecdotes and individual reports, there is little research evidence suggesting that ozone has an effect on the brain.

A new paper produced by Dr. Jay Buckey, a physician and astronaut, in the journal of Cellular Neurophysiology suggests that ozone may have effects past the eardrum. This would mean that ozone could have a positive effect on the inner ear and potentially further into the brain.

If this is the case, it is likely that ozone itself does not travel to the inner ear, but creates a chain reaction, known as a cascade effect. Other tissues in the body, like the blood or rectum, ozone interacts with the products and creates reactive oxidant species and lipid peroxides. There are byproducts often created from oxidative stress, which can be bad if your body has too much. This small stimulation from ozone therapy causes the body to react in a positive manner, thus bringing benefits.

Many people compare ozone therapy with exercise. Exercise stimulates stress within your body. Your body then recognizes that stress and heals itself to be stronger and healthier than before. In the same way, ozone therapy, when done correctly, often stimulates a very small stress which causes a large response in the body to healing, reparation, and homeostasis.

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Done correctly and with the proper equipment, ozone ear insufflation has minimal risk. There are some reports of irritation to the ear canal due to too strong of a dose or sensitivity to ozone. If irritation occurs, people generally discontinue the use of ozone ear insufflation or reduce the length of the therapy to decrease the dose. The irritation is not permanent and should resolve itself quickly.

Ozone cannot be breathed into the lungs because it will irritate the lung tissue. Prolonged exposure at high concentrations may be cause for health concerns. Doctors and scientists who use ozone claim that it is one of the safest therapeutic modalities known to man. A complete review on the safety of ozone therapy can be read here.

Contraindications/Reasons to Avoid Ozone Ear Insufflation

  • Punctured Eardrum
  • Pregnancy
  • Ozone sensitivity or allergy
  • Perhaps more but more studies are needed. Clinically, practitioners generally only avoid ear insufflation ozone therapy for the above reasons.

Negative Side Effects

If you experience these symptoms, discontinue and contact your medical professional. There are no reports of these negative side effects causing permanent damage. Practitioners often explain these negative side effects as one of three things.

  1. Herxheimer reaction, where ozone quickly kills off bacteria and byproducts are produced, causing irritation and inflammation. AKA “Detoxification is occurring too fast.”
  2. Ozone begins to remove blockages in the ears
  3. An ozone allergy or sensitivity
  4. Too much ozone is used

Ozone is very dry and may cause further dryness in the ears. This is why ear insufflation often uses a humidifier for the ozone gas.

  • Pain
  • Itching
  • Liquid Discharge from Rash or Blockage
  • Tinnitus
  • Scabbing
  • Swelling

Use with Antibiotics

Ozone does not seem to have negative interactions with antibiotics. Consult your practitioner before using ozone.

Ozone Therapy Equipment

All parts of the medical grade ozone generator and equipment used must be ozone resistant to avoid contaminants in the gas (316SS, Titanium, Silicone, and Quartz Glass are acceptable materials).

Ozone Equipment Needed

  • Medical grade ozone generator
  • Oxygen Tank
  • Oxygen Tank Regulator
  • Ozone Bubbler System
  • Ozone Stethoscope
  • Fan and/or 3M Mask for avoiding breathing the ozone

If you already have a medical ozone generator, it will cost $200 to get set up. If you don’t have a medical grade ozone generator, it will cost about $950 for everything.

If done at a doctors office, it often costs between $30 – $100 per treatment.

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Ozone Therapy Procedure

Here is a video that explains how to perform ozone ear insufflation:

Ozone Ear Insufflation Instructions

Duration: 3 – 10 minutes, start low and work your way up. Reduce duration or discontinue if negative side effects are noticed.

Concentration of Ozone: 10 – 30 ug/ml (gamma)

Flow Rate of Gas: 1/16 – ¼ Liters Per Minute (LPM)

Frequency: As needed up to daily. Most commonly, 2 – 3x per week. Discontinue if irritation or pain occurs. Sensations of warmth are normal.


This article is intended for informational purposes only and is not intended to be medical advice. Seriously.

Ask advice from your medical practitioner before trying anything like this or relating to ozone therapy. You should listen to the counsel of your medical practitioner.

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

This site offers medical information about treatments and remedies which are available in other countries completely legally, but in no way should anyone consider that this site represents the “practice of medicine.” This website assumes no responsibility for how this material is used.

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Free Guide on Ozone Therapy

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