Effects on the Brain
Beyond anecdotes and individual reports, there is little research evidence suggesting that ozone has an effect on the brain.
A new paper produced by Dr. Jay Buckey, a physician and astronaut, in the journal of Cellular Neurophysiology suggests that ozone may have effects past the eardrum. This would mean that ozone could have a positive effect on the inner ear and potentially further into the brain.
If this is the case, it is likely that ozone itself does not travel to the inner ear, but creates a chain reaction, known as a cascade effect. Other tissues in the body, like the blood or rectum, ozone interacts with the products and creates reactive oxidant species and lipid peroxides. There are byproducts often created from oxidative stress, which can be bad if your body has too much. This small stimulation from ozone therapy causes the body to react in a positive manner, thus bringing benefits.
Many people compare ozone therapy with exercise. Exercise stimulates stress within your body. Your body then recognizes that stress and heals itself to be stronger and healthier than before. In the same way, ozone therapy, when done correctly, often stimulates a very small stress which causes a large response in the body to healing, reparation, and homeostasis.