Wound Healing 2018-09-04T10:09:59+00:00

Wound Healing with Ozone Therapy


Ozone therapy can speed up the healing process for wounds, and it has been widely recognized as one of the best bactericidal, antiviral and antifungal agents.  Ozone peroxides and ozonides form to stimulate wound healing. It is non toxic, safe and effective for even antibiotic-resistant bacteria such as MRSA. It can be applied as a gas, liquid (in saline or distilled water) or ozonated oil.

Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol 2005;153:1096–1100.


On the left are images that display the effects of ozonated olive oil on clinical wound closure for a guinea pig.  Points a and b in the photomicrographs demonstrate the enhanced wound closure in the ozone group. Point c represents the oil group and point d is the control group.

wound and nurse
For an impressive look at ozone healing on a necrotic tissue after a bone break, click here (warning: not for the faint of heart!)

Some infected or fresh wounds need a stronger concentration of ozone via limb bagging, ozonated saline, or ozonated water. The liquids wash the wound and kill bacteria and viruses. After a day or so, lower concentrations of limb bagging or ozonated oils are used to promote healing. Stronger concentrations of ozone will actually retard healing after the initial cleansing takes place.

The following graph displays a common German procedure for topical ozone application:

IndicationOzone ConcentrationForm Of ApplicationTreatment Time Treatment Frequency
Decubitus ulcers After wound cleansing 80–100µg/ml beginning 20–30µg/mlLow pressure suction cup 2–10 min Daily first then 2×per week
Diabetic gangrene after wound cleansing80–100µg/ml beginning 20–30µg/mlLow pressure plastic bag10–20 min Daily first, then 2×per week
Ulcus cruris Wound cleansing80–100µg/ml beginningPlastic bag (not low pressure!)10–20 min Daily first, then 2×per week
Wound healing20–30µg/mlCompresses + rinsing with ozone water1–5 min several times daily
Burns stage 1 and 220–30µg/mlPlastic bag, compresses + rinsing with ozone water10-20 minutes 1–5 min First 1–2× per day, several times per day