Ozone Oil

Uses, Benefits, and How to Get Your Hands on Some
Table of Contents


  • Standard healthcare programs do little to help the 1.5 billion people affected by skin and mucosal infections 
  • Ozone oil may be effective for a multitude of skin issues because it's a strong antiseptic that stimulates the body's healing processes
  • Not all ozone oil is created equal 

Over the past few decades there has been a drastic increase in skin infections. The standard healthcare system hasn't done a good job of eliminating these skin issues, which range from bacteria to diabetes and everything in between. 

Although these are not usually deadly, they still pose an epidemic problem because the standard care is expensive and not very effective.

Enter ozone oil, the use of which is said to "appear providential" because of how it works with all of these skin issues.

What is Ozone Olive Oil?

Organic Ozonated Olive Oil is created when ozone-oxygen gas is infused into oil. It’s a lengthy process that ozonates the oil by creating peroxides.

Ozonated olive oil is commonly used for acne, wrinkles, eczema, psoriasis, skin infections, athletes foot, and more.

Dr. Velio Bocci writes this about ozonated olive oil:

“The ozonated oil is now used topically for the treatment of war wounds, anaerobic infections, herpetic infections (HHV I and II), trophic ulcers and burns, cellulitis, abscesses, anal fissures, decubitus ulcers (bed sores), fistulae, fungal diseases, furunculosis, gingivitis and vulvovaginitis.”

What is Ozone Oil Used For?

Before I get into how ozone oil works, here’s a quick list of what it typically treats:

  • Acne
  • Rosacea
  • Wrinkles 
  • MRSA
  • Infected Wounds
  • Non-Healing Wounds
  • Ulcers
  • Oral Infections
  • Receding Gums
  • Eczema
  • Psoriasis
  • Athletes foot
  • And much more

How does ozonated olive oil work for so many (50+) issues? 

For such a remarkable modality that can treat so many things, the way ozone oil works is surprisingly simple. It only does two things:

  1. Kills pathogens - Infections, acne, and many issues on the skin are caused partly by bad bacteria. Ozone oil kills bad bacteria and restores the skin. It stimulates the natural production of hydrogen peroxide in the tissue. Your body makes this already, ozone oil just upregulates how much is produced.
  2. Regenerates Collagen and Speeds Healing -  As you age, your collagen is damaged and reduced — which makes your skin more wrinkly and older-looking.  Ozone oil stimulates growth factors and the regeneration of collagen.

Your skin naturally learns to repair and build itself. Ozone oil simply stimulates that built-in process. 

There are no known negative effects of using ozone oil.  

As a scientist, Dr. Velio Bocci devoted the majority of his career to ozone and spent over 30 years researching it in Italy.

Some time ago, Dr. Velio Bocci wrote:

"I would like to predict that the application of ozonated oil, a simple and inexpensive remedy, will become far more useful than expensive pharmaceutical creams and will herald a medical revolution for the topical treatment..."

Our bodies run on oxygen. And one of the things that ozone can do is slowly diffuse oxygen to the affected area.

Acne patient before and after use of ozone oil

Acne patient before and after use of ozone oil

Eczema patient before and after use of ozone oil

In a nutshell, for all you science nerds, here are studies demonstrating how ozone oil works:

  • "assays showed that ozone oil up-regulated collagen I, α-SMA, and TGF-β1 mRNA and protein levels in fibroblasts"
  • Wound healing with oil control - shows effect of the ozonated oil vs. standard oil.
  • "Based on the results from the wound closure between the ozone group and the oil group on days 0, 3, 5, 7, and 11, the ozone group showed a significantly smaller wound size and residual wound area than the oil group"
  • "Ozonated oils have demonstrated activity and can be proposed for use in the prevention and treatment of chronic local infections, in appropriate formulations and in controlled cases, as an alternative to topical antimicrobial agents. This can be useful as an alternative to contrast the widespread and indiscriminate use of topical agents, particularly mupirocin and fusidic acid, which has led to the emergence of bacterial resistance"

“I have tried many other creams, ointments and pills to help an inflamed area of my body…skin- topical, possibly histamine related.  Thanks to Simply O’s oil that layer of inflammation has subsided.” (source)

“Helped with psoriasis keeping it under control.  No crazy medications or things in it that cause adverse reactions like so many psoriasis specific meds.” (source)

What Applications are Ozone Oils Used In?

Ozone oil is a multi-purpose product that can be used for a wide range of issues. 

  • Cosmetic purposes - Acne, wrinkles, rosacea, sores, and blemishes
  • Medical Purposes - MRSA, ulcers, non-healing wounds, burns, rashes, 
  • Tooth and Gum Purposes -  Receding gums, cavitations, infections, sores, post-surgery
  • Gut Health - Consuming organic ozone oil capsules is helpful for parasites, stomach ulcers, and gut health.
  • Vaginal and Rectal infections - Ozone oil suppositories can be used in the form of a suppository to assist with infections in the vagina and rectum without harming the biome.

The difference between high and low quality ozone oils

  • Ozone oil made to high standards absorbs much better
  • Ozone oil made to high standards works much quicker
  • Lower quality ozone oil is produced inconsistently, often with too much guesswork involved 

There is a major problem in the ozone oil industry as shown in this study.

  1. Most companies go based on how it looks to determine when it’s done.  They never actually know how strong the oil is, so every batch differs.  
  2. Every company (with one exception) uses a heated production method which creates inflammatory compounds and can cause irritation/breakouts.

For a long time, ozone oils were lacking standardization and needed improvement. None of the manufacturing methods had a way to measure the peroxide value (which is the gold standard of measuring ozonated oils). It was somewhat of a crapshoot. To put it bluntly (and oversimplified), people just saturated oil until it looked a certain way.

This issue is more widely understood in Europe but hasn't broken into the USA yet.  Simply O3 Ozone Oils utilize cold production methods to make the ozone oil and can measure the amount of peroxides in the oil. 

There were — and still are — some other issues with the way many ozone oils are manufactured, but inconsistency is the biggest one: it’s hard to be 100% sure what you’re getting. One oil could be different from the next.

 Simply O3 Ozone Oils use European pharmacological standards to create a product that is going to be stable and reliable each and every time. It’s also more absorbent, allowing for deeper penetration and a much faster response time. 

I’m not trying to bash any of the other ozone oil companies. I believe they provide a great product with stellar results — it's unlikely you would be upset with a purchase. But there is still room for improvement. 

A synopsis from this study states, “Dozens of companies and web sites may be easily found to buy ozonated oil. But, very few of these products are reliable, and contain sufficiently ozonated oil”

Simply O3 knows exactly how ozonated their oil is due to the standardized practice and measuring of how many peroxides are in the oil.

I'm not just paying lip service to this particular product. After offering ozone oils for eight years, I realized I couldn’t (and shouldn’t) settle for anything less. 

Formaldehyde is in most ozone oil

Unfortunately, there is a large elephant in the room of the ozone oil industry. 

Formaldehyde is produced during a heated process and is toxic to the skin and body.

One study writes, 

“Formaldehyde is a by-product of the vegetal-oil ozonation process. Although it is a compound with antibacterial activity, formaldehyde is also a toxic product, and can affect cellular integrity.”

Formaldehyde is produced during the ozonation of oil because a chemical reaction occurs when the heat is too high.

How do I know if formaldehyde is in the oil?

  • A production other than COLD was used (heat, “no heat”, low heat don’t work).  The ozone oil must be produced under COLD conditions.
  • The oil comes in a jar and has a paste like consistency

A cold produced oil will have a consistency similar to the base oil.  If it’s too thick, there was too much heat added.


For the above reasons, I recommend Simply O3 ozone oil.

Dr. Kayte Susse


Applying ozone oil is straightforward.  Rub it into the affected area.  The intensity of the issue will determine the frequency.  You can’t necessarily overdo it.

  • For Beauty and Acne - Apply to the desired area nightly before bed.  Rub it in well.
  • For infections - Apply to the affected area 3x daily until resolved
  • For eczema/psoriasis/rashes - Rub into the affected area 2x daily.  Keep in mind, this does not resolve the underlying issue but may help with flare-ups.

Buying vs. Making Ozone Oil at Home

Knowing what I know, I would recommend buying ozone oil over making it at home.  Here’s why:

  • It is not going to save money unless you make A LOT and use A LOT.  
  • You need to keep a constant eye on the ozone oil, it can bubble over and out of the bubbler due to the heat.
  • You will not be able to make it to the same strength as professional grade oils.  They are made to European pharmacological standards and use commercial grade equipment.

If you are a DIY type of person, you might enjoy making ozone oil.  But for most people, it’s more time, cost, and benefit effective to buy it instead.

How to Make Ozone Oil at Home

Equipment Required:

Warning: Although unlikely, This process can produce oil fumes that travel back into the ozone generator - this could potentially cause a fire.  This article is for educational purposes only.

Ozonating Oil at Home:

  1. Turn the ozone generator on
  2. Do not leave the room while operating
  3. Open the valve of your oxygen tank by rotating counter clockwise
  4. Turn regulator knob to 1/4 LPM (Setting 5 for the Stratus 3.0 and Ozone+ Regulator)
  5. Let run for 4 hours.
  6. Turn off generator and oxygen for 2 hours.
  7. Repeat until the oil is white paste.  You can get some benefits from the oil even after 4 hours of ozonation.


Ozonated oil has been around for a long time and seems to be tremendously helpful for infections, blemishes, acne, wounds, and more.  It is a multi-purpose product that is natural and can be used on almost anything because it stimulates natural healing.  

If you're interested in trying ozone oil, I highly recommend checking out Simply O3 ozonated oils.Click here to view their products.

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