Used intradiscally or intramuscularly, ozone stimulates an acute but tolerable oxidative stress giving a hormetic-type response to regenerating the joint.
Intra-articular or periarticular insufflation of small volumes (5–15 mL) of a gaseous mixture of O2–O3 (ozone concentrations ranging from 5 to 25 μg/mL).
Ozone can surprisingly display a number of beneficial effects, ranging from the inhibition of inflammation, correction of ischemia and venous stasis to finally inducing a reflex therapy effect by stimulating anti-nociceptor analgesic mechanisms.
Ozone therapy’s ability to reactivate the innate antioxidant system is the key to correcting the oxidative stress from inflammatory diseases and injuries. It works with the pain pathways and control systems of algesic signals.
The image displays routes of an ozone injection into the lumbar region.
Ozone gas is commonly injected by itself for the effects described above.
Cost to patient: $70 - $150 per injection
Methyl B12, pyridoxine, dextrose, and procaine is mixed into a solution and injected prior to the ozone.
Cost to patient: $100 - 250 per injection
Blood is drawn from the patient and spun down to expose the platelet rich plasma. Ozone is added to create super PRP by activating the platelets and increasing the growth factors. Image taken from study, “Role of Ozone/Oxygen in Fibroblast Growth Factor Activation.”
Ozone is used as a pre and post treatment to stem cells/exosomes. Commonly done two weeks before and two to six weeks after. In addition to stand alone benefits, ozone helps to create a more effective environment and increase the efficacy of the stem cell treatment.