What Is The Best Type Of Ozone Administration?

Comparison Of Systemic, Localized And Topical Ozone Administration

What You Should Know About Administering Ozone Therapy

The simple answer to this question is that there is no single “best” way to administer ozone. Depending on your physical condition and what you hope to accomplish, there are several methods of ozone administration you might choose from.  You’ll find the pros and cons of the most common types of ozone administration below: systemiclocalized, and topical.

Drs Ozone provides information on common ozone therapy protocols here.

Systemic Ozone Administration

There are only two types of ozone administration that are systemic (affect the entire body): ozonated autohemotherapy (injection of ozone into the bloodstream via IV), and rectal insufflation (releasing ozone gas into the body via the rectum). Both have their pros and cons. Here they are.

Ozonated autohemotherapy (IV Ozone)

Intravenous administration of anything should only ever be performed by a medical professional in a sterile environment. For this reason, IV ozone is the only method of ozone therapy that cannot and should not be administered at home.

With these safety cautions in mind, IV ozone is considered the most effective type of administration currently available. This is because ozone is injected directly into the bloodstream, which allows it to be distributed throughout the entire body almost immediately, affecting every system in the process.

Although some patients have reported a slight burning sensation with IV administration (a common complaint for all types of IV administrations, not just ozone), the biggest downsides of IV administration are inconvenience and high cost. Since IV ozone can only be administered by a medical professional in a clinic, treatments generally cost more than $100 each session. A typical course of ozone therapy is between 6-10 treatments, so while IV administration is the most effective, it is also the most expensive.

Rectal Insufflation

Rectal insufflation is the process of releasing ozone gas into the body through the rectum. Since the colon walls easily absorb gases, rectal insufflation has been carefully studied and claimed by many to be 95-96% as effective as IV ozone.

This is because, when inserted via the rectum, ozone is absorbed through the colon walls and is distributed throughout the bloodstream. So while IV ozone is injected directly into the bloodstream, rectal insufflation still affects the bloodstream, just not as quickly or directly.

Despite this slightly lesser efficacy than IV ozone, the only other downside of rectal insufflation is the slight discomfort some users report after their first experience.

Otherwise it seems the pros of rectal insufflation far outweigh the cons (after you get past the name). Rectal insufflation can be self-administered at home with the right equipment and minimal training, saving users the added expense and inconvenience of traveling to the clinic for every treatment (though many integrative practitioners also offer rectal ozone in their clinics). And while IV ozone administration costs upwards of $150 for each treatment session in the clinic, rectal insufflation at home may have the potential to become only cents per treatment after the initial purchase of the necessary equipment. If you’re beset with a chronic illness like cancer, autoimmune disease, Lyme disease or something similar, consider using rectal ozone at home as only supplemental to IV ozone in the clinic until you feel well enough and your doctor advises you to transition to doing all your rectal ozone treatments at home.

View the protocol for rectal insufflation here.

Localized Ozone Administration

While systemic ozone administration is the usually the best option for people who want to resolve internal issues and treat many different diseases, the following types of localized ozone administrations are intended for treatment of only certain areas and/or disorders.

Limb Bagging

Limb bagging is obviously only used for limbs. When there is a wound, burn or infection on the skin of a limb (whether a leg or arm), a limb bag is used to fully enclose the limb, and ozone from a generator flows into the bag, exposing that layer of skin to the antiseptic and healing power of ozone.

View the protocol for limb bagging here.

Vaginal Insufflation

The process of vaginal insufflation involves ozone flowing from a generator via a specialized attachment into the affected area and back out into an ozone destruct to prevent any excess ozone from entering the air.

Vaginal insufflation is generally used to treat yeast, bacterial and viral vaginal infections as well as pain in and around the vagina and pelvis.

View the protocol for vaginal insufflation here.

Ear Insufflation

When there is an ear or sinus infection, ozone can be used to oxidize and treat the infection. Ozone is introduced into the ears via a specialized stethoscope and humidified via an ozone bubbler system to make the ozone gas more comfortable and effective (while ozone breaks down in high humidity, a little bit of moisture helps avoid irritation and aids in penetration of the ear/sinus cavities). For more information about Ozone Ear Insufflation, you can read this article on our blog.

Check out our video on Ozone Ear Insufflation here.

Ozone Cupping

Much like limb bagging, ozone cupping is used to expose affected areas of skin to the antiseptic, oxygenating power of ozone. A specially designed glass ozone cup is attached to an ozone generator and ozone flows into the cup, exposing the affected skin and flowing back into a built-in ozone destruct for safety.

Read the protocol for ozone cupping here.

Topical Ozone Administration

Medical grade ozone doesn’t always require a generator and special equipment in order to benefit your health. Below are a couple of alternative ways to use ozone.

Ozone Creams And Gels

Ozone creams are made from a base of ozonated oil (particularly natural oils such as olive oil or sunflower seed oil), and are applied topically to the skin for things like acne, blemishes and rashes. The active ingredient of ozone releases lipids and peroxides into the skin and quickly turns back into oxygen, working with the skin’s natural cleansing functions instead of forcing something unnatural to happen with harsh, man-made chemicals.

In a similar way, ozone gels and pastes are used in the mouth to eradicate pathogens, cut infections in cavitations and promote overall tooth health without the long-term damaging effect of unnatural chemicals like fluoride.

Ozone Water

Ozone water has a variety of uses, including topical application on the skin (for safe antiseptic purposes), sterilization of produce and other fresh foods, or even drinking directly. There isn’t as much scientific evidence in favor of drinking ozone water as there is in favor of using it as a disinfectant, but ozone is often used for water purification , and it’s much safer than chlorine or fluoride. That being stated, there is a lot of anecdotal evidence to support the opinion that drinking ozonated water leaves those who drink it feeling refreshed and energized from the activated oxygen.

However you choose to use it, just keep in mind that room temperature ozone water has a half life of around 20 minutes, meaning that within that time frame the ozone breaks down into oxygen and you’re left with regular water. Chilling it can extend the half life, but not by much. The sooner ozone water is used after it’s made, the better. An ozone water bubbler is required to saturate distilled water (make sure it’s distilled) with ozone via an ozone generator, and can be done easily at home.

View the protocol for making ozone water here.

We’ve also created a video on the topic of Ozone Water – View it here.

Learn About Ozone Equipment


Hopefully this article helped you see that there are several ways to safely and effectively administer ozone, but each has its own specialty.

However you choose to use ozone, be sure to never breathe it in. Ozone is a safe and effective tool when used properly, but it will cause lung irritation if it’s inhaled. This is the reason an ozone destruct is so important during ozone administrations, so no excess ozone has the chance to enter your lungs. Some ozone generators come with a built-in destruct, but if yours doesn’t, a separate ozone destruct is worth the investment.

Continue exploring this website or talk to an integrative practitioner who offers ozone therapy to determine which type of ozone therapy is best for you and your situation.

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